Succinylated Octopamine Ascarosides and a New Pathway of Biogenic Amine Metabolism
نویسندگان
چکیده
Received for publication, April 12, 2013, and in revised form, May 13, 2013 Published, JBC Papers in Press, May 20, 2013, DOI 10.1074/jbc.C113.477000 Alexander B. Artyukhin, Joshua J. Yim, Jagan Srinivasan, Yevgeniy Izrayelit, Neelanjan Bose, Stephan H. von Reuss, Yeara Jo, James M. Jordan , L. Ryan Baugh , Micheong Cheong, Paul W. Sternberg, Leon Avery, and Frank C. Schroeder From the Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, the Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, Virginia 23298, the Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena, California 91125, and the Department of Biology, Duke Center for Systems Biology, Duke University, Durham, North Carolina 27708
منابع مشابه
Succinylated octopamine ascarosides and a new pathway of biogenic amine metabolism in Caenorhabditis elegans.
The ascarosides, small-molecule signals derived from combinatorial assembly of primary metabolism-derived building blocks, play a central role in Caenorhabditis elegans biology and regulate many aspects of development and behavior in this model organism as well as in other nematodes. Using HPLC-MS/MS-based targeted metabolomics, we identified novel ascarosides incorporating a side chain derived...
متن کاملSimulation of biogenic amine metabolism in the brain.
The metabolism of a number of biogenic amines has been simulated by using data obtained from studies of the individual enzymes from pig brain. It is shown that beta-hydroxylated amines such as noradrenaline and octopamine are metabolized primarily to the alcoholic metabolite whereas amines lacking this group [e.g. dopamine (3,4-dihydroxyphenethylamine) and 5-hydroxytryptamine] are metabolized a...
متن کاملFly Fighting: Octopamine Modulates Aggression
The genetics and neurobiology of Drosophila aggression are still poorly understood. A new study using an automated method to analyze one component of male fly aggression has shown that the biogenic amine octopamine plays a role in the modulation of aggressive behavior.
متن کاملElevated levels of circulating trace amines in primary headaches.
BACKGROUND Trace amines, including tyramine, octopamine, and synephrine, are closely related to classic biogenic amines. They have been hypothesized to promote migraines and other types of primary headaches, but there is no direct evidence supporting this hypothesis. METHODS Using a multichannel electrochemical high-performance liquid chromatography system, the authors evaluated whether chang...
متن کاملA novel octopamine receptor with preferential expression in Drosophila mushroom bodies.
Octopamine is a neuromodulator that mediates diverse physiological processes in invertebrates. In some insects, such as honeybees and fruit flies, octopamine has been shown to be a major stimulator of adenylyl cyclase and to function in associative learning. To identify an octopamine receptor mediating this function in Drosophila, putative biogenic amine receptors were cloned by a novel procedu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2013